Gene's Addiction, or Why Ozzy Osbourne Is Still Alive

Our genes might play a role in influencing who falls prey to addiction.

By Bill Sullivan
Oct 10, 2019 2:14 PMMay 9, 2020 10:27 PM
Addiction-Header.jpg
(Credits: Collage by Sarah Hanson; KrulUA/istock; Shutterstock: Triff, Zita, Paparacy, Rawpixel.com, SunnyToys, Africa Studio, Nestor Rizhniak, Monika Wisniewska, Best_photo_studio, Namning, I love coffee)

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Nowadays, you can sequence your genome in a weekend for about a thousand bucks. But would you believe that the first human genome sequenced took 13 years (1990 to 2003) and cost $2.7 billion?

Back in those days, when Harry Potter had just started his on-screen adventures at Hogwarts, getting your genome sequenced was a rare privilege. Among the first people to remove the invisibility cloak from their DNA were James Watson, one of the scientists who helped solve the structure of DNA in 1953, and Craig Venter, who was instrumental in making the Human Genome Project happen. Steve Jobs was also one of the first to have his genome sequenced (which I imagine lab techs referred to as the iGenome). What other luminaries did scientists reach out to for secrets their DNA held? Stephen Hawking? High IQ record-holder Marilyn vos Savant? That guy who won 74 games in a row on Jeopardy?

Nope. Scientists wanted Ozzy Osbourne.

Born in 1948, John Michael Osbourne answers to several names, including “Ozzy,” “Prince of Darkness” and “Godfather of Heavy Metal.” Ozzy rose to stardom with Black Sabbath in the 1970s, and then went on to a wild, and wildly successful, solo career. But Ozzy’s music has often been eclipsed by his legendary drug and alcohol binges. So why would researchers want to peek inside Ozzy’s genes?

Truth be told, Ozzy is a remarkable human specimen. He’s constantly struggled with addiction to multiple vices (cocaine, booze, sex, pills, burritos), tirelessly toured and partied for half a century and survived reality television while taking up to 25 Vicodin pills a day at the time. His immune system was so weakened from drugs and alcohol that he once falsely tested positive for HIV.

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